Bisphosphonates and Osteonecrosis of the Jaw: A by Francesco Saverio De Ponte

By Francesco Saverio De Ponte

in the course of the early nineteenth century, it used to be chanced on that including yellow (now referred to as white) phosphorous to matchstick heads made it more uncomplicated to ignite fits. The phosphorous vapors have been breathed in via employees and mixed with different chemical compounds within the physique to supply a effective nitrogen-containing bisphosphonate. brand new oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates movement round the physique an identical approach because the phosphorous vapors, and are absorbed into bone and ingested by means of osteoclasts. while this special binding technique of bisphosphonates to bone happens, osteoclasts are poisoned, and this reduces or removes bone turnover. Alveolar bone within the mandible and maxilla turns over extra swiftly than in lengthy bones, so the jaws are a greater aim for bisphosphonate toxicity. It wasn't until eventually 2003 that latest intravenous and oral nitrogen-containing bisphosphonate drugs have been implicated as significant threat components within the improvement of uncovered necrotic bone of the jaws. lots of the researchers who stated circumstances of bisphosphonate-induced osteonecrosis of the jaw came upon that those sufferers have been taken care of with zoledronate, pamidronate, or a mixture of those medications, that are time-honored for treating breast melanoma or myeloma. In approximately five% of situations, matters with BIONJ have been being handled for osteoporosis. Precipitating occasions that give a contribution to BIONJ are enamel extractions (about 50% of cases), mandibular exostoses, periodontal illness, and native trauma from ill-fitting dentures. it's not identified if the location of dental implants is a precipitating issue. The e-book goals to fulfill the necessity of scientific practitioners operating in all fields that use bisphosphonates, and to provide the conservative and surgical procedure equipment at present in use. there'll even be specific info at the literature when it comes to dental implants in sufferers handled with bisphosphonates.

Show description

Read or Download Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach PDF

Similar dentistry books

The Fearful Dental Patient: A Guide to Understanding and Managing

The frightened Dental sufferer: A advisor to figuring out and coping with is helping dental pros comprehend the fundamentals of worry, nervousness and phobias and the function those feelings play in developing unfavourable habit in the dental surroundings. The textual content encompasses a number of modalities that aid determine dental worry and phobia, in addition to chair-side options and sensible recommendation geared toward enhancing sufferer cooperation and making sure remedy compliance.

Nanobiomaterials in Clinical Dentistry (Micro and Nano Technologies)

New nanomaterials are resulting in more than a few rising dental remedies that make the most of extra biomimetic fabrics that extra heavily replica normal the teeth constitution (or bone, in terms of implants). This booklet brings jointly a world crew of specialists from the fields of fabrics technology, nanotechnology and dentistry, to provide an explanation for those new fabrics and their functions for the recovery, fixation, substitute, or regeneration of challenging and gentle tissues in and in regards to the oral hollow space and craniofacial quarter.

Fundamentals of Periodontal Instrumentation and Advanced Root Instrumentation

Strolling dental hygiene scholars step by step in the course of the “how to”—not simply the “what” and “why”—of utilizing periodontal and root tools, this eighth version of Jill Gehrig’s definitive source good points new chapters, new on-line method movies, up to date assurance of the most recent evidence-based suggestions and gear, and an extended array of on-line educating and studying assets.

Atlas of Complex Orthodontics - E-Book

Introducing the Atlas of advanced Orthodontics, a progressive new textual content with step by step directions for treating today’s hardest orthodontic situations. Over 1,500 full-color scientific pictures, radiographs, and illustrations current each one part of remedy during this atlas-style consultant, beginning with the pre-treatment work-up, carrying on with throughout the therapy series, and finishing with the ultimate effects.

Additional resources for Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach

Sample text

Download PDF sample

Rated 4.65 of 5 – based on 11 votes